How long does it take for Prozac to reach steady-state concentrations based on its half-life?

Jan 17, 2017 ... Fluoxetine has unique pharmacokinetic properties, probably what distinguishes fluoxetine from other SSRIs is its long half-life. Most SSRIs have ... Aug 2, 2022 ... Then wait perhaps 1, 2, or more weeks for things to settle before the next cut. Expect withdrawal symptoms to emerge around the drug's half-life ... Sep 16, 2011 ... ... (Prozac), the risk of experiencing symptoms related to a decrease in the medication is low. That's because fluoxetine has a long half-life ... The half-life of its active metabolite, norfluoxetine, is about 7 to 9 days. Metabolism: Fluoxetine is extensively metabolized in the liver to a desmethyl ... PO, metabolized in the liver primarily by CYP2D6, with fluoxetine (parent drug) having a half life of several day half life of 1-4 days · norfluoxetine is an ... Its mean terminal half–life after a single dose was 8.6 days and after multiple dosing was 9.3 days. Steady–state levels after prolonged dosing are similar to ... Jan 5, 2020 ... For many people, antidepressants can be literal lifesavers. But not everyone wants to stay on them indefinitely, and herein lies the problem: ... Withdrawal symptoms (also called antidepressant or SRI discontinuation syndrome) are unpleasant physical and mental effects from reducing the dose of or ... 1 The half- lives of sertraline and fluoxetine in dogs are 26 and 20 hours, respectively.8 The half-life of paroxetine is 20 hours, but it increases in ... Jan 12, 2023 ... Prozac has a half-life that can range from 1-3 days depending on the amount of time the individual was on the drug. Longer-term usage of Prozac ...