How does the distribution of Prozac into tissues affect its elimination half-life?

In general, manufacturers advise caution (prolonged half-life). Hepatic impairment For fluoxetine. Dose adjustments. Manufacturer advises dose reduction or ... Jun 25, 2021 ... A randomized placebo-controlled clinical trial suggested that shorter half-life antidepressants may be at higher risk of withdrawal syndrome ... A sensitivity analysis found that removing responses involving fluoxetine, which has an especially long half-life, did not significantly alter this result. Feb 19, 2008 ... Fluoxetine, marketed under the brand name Prozac ... The period is longer in the former incidence because of the long half-life of fluoxetine in ... Jun 27, 2018 ... The half-life of Fluoxetine is about 2 to 7 days; however, norfluoxetine lasts longer with a half-life of 4 to 15 days. Fluoxetine stays in the ... May 11, 2020 ... ... fluoxetine profile. In fact, due its long half-life and to the time required to induce changes at serotonergic receptor levels, fluoxetine ... The half-life of Prozac is initially about one to three days, though with continued use, that extends to four to six days. The drug is 99 percent out of your ... Jul 1, 1997 ... ... half-life of fluoxetine and 7- to 9-day half-life of norfluoxetine. Bruising and bleeding disorders have also been described with fluoxetine use ... Many people don't see them until a couple weeks after they've stopped taking Prozac because Prozac has a longer half-life than other antidepressants. As a ... Feb 17, 2023 ... Fluoxetine may still cause medicine interactions 5 or 6 weeks after stopping as fluoxetine and its active metabolite have a long half-life.