What are the typical therapeutic ranges for plasma concentrations of Prozac and norfluoxetine?

The elimination half-life of fluoxetine is 48–72 h, averaging almost 70 h. The half-life of norfluoxetine is 7–9 days. The elimination half-lives for both ... PO, metabolized in the liver primarily by CYP2D6, with fluoxetine (parent drug) having a half life of several day half life of 1-4 days · norfluoxetine is an ... Jul 10, 2001 ... ... SSRI plasma concentration and normalized more slowly, corresponding to the drug plasma half-life of about 10 days. The REM fraction of the ... These studies suggest that fluoxetine has a long half-life, which contributes to its steady presence in the bloodstream, potentially leading to fewer side ... ... fluoxetine's long half-life. (compared to other antidepressants that can be washed out more quickly). ⦁ Also due to long half-life, effects of dose changes ... Relative bioavailability of each dose administered via the TD route was 10% of the value for oral administration of the drug. Mean plasma elimination half-life ... Because fluoxetine and its major metabolite, norfluoxetine, have long half-lives, a 6-week washout inter- val should be observed following discontinuation ... Feb 19, 2008 ... Fluoxetine, marketed under the brand name Prozac ... The period is longer in the former incidence because of the long half-life of fluoxetine in ... The long elimination half-lives of fluoxetine and norfluoxetine assure that, even when dosing is stopped, active drug substance will persist in the body for ... Apr 17, 2023 ... Prozac works by inhibiting the reuptake of serotonin, allowing it to stay in the brain for longer periods and enhancing its effects.