How does the long half-life of Prozac influence its effects on muscle cramps or weakness?

The speed with which a specific antidepressant can be stopped is largely related to its half-life. Agents with very long half-lives, such as fluoxetine (half- ... The elimination half-life of fluoxetine is about 1 to 4 days, while that of its metabolite norfluoxetine ranges from 7 to 15 days. Fluoxetine has a nonlinear ... May 15, 2022 ... Antidepressant withdrawal symptoms ; Drug. Half out of body in. 99% out of body in ; Serotonin reuptake inhibitors ; paroxetine (Paxil). 24 hours. May 31, 2024 ... Also, fluoxetine has a comparatively longer half-life (48-72 hours compared to 27-33 hours for escitalopram), resulting in a more prolonged ... Hepatic. Elimination. Renal. Half-life (fluoxetine): 1–3 days (acute); 4–6 days (chronic) ... ... fluoxetine's long half-life. (compared to other antidepressants that can be washed out more quickly). ⦁ Also due to long half-life, effects of dose changes ... Mar 29, 2025 ... Fluoxetine has a long half-life, which can be a concern in certain patient populations, particularly older adults, due to its potential for ... Jun 27, 2018 ... The half-life of Fluoxetine is about 2 to 7 days; however, norfluoxetine lasts longer with a half-life of 4 to 15 days. Fluoxetine stays in the ... Apr 24, 2023 ... • Drug half-lives can vary drastically. • Fluoxetine (Prozac) has a half-life of 4-6 days and has an active metabolite (norfluoxetine) that. Administering a drug less than once per day is generally not done, however. The ideal antidepressant would have a half-life consistent with once-a-day dosing or ...