Are there any specific pharmacokinetic considerations when using Prozac for these off-label indications?

Jun 27, 2019 ... These include fluoxetine (aka Prozac), paroxetine (aka Paxil) ... half life of 20-100 hours). These can be highly addictive. These are ... The half-life of Prozac is about 4 to 16 days. A drug's half-life describes how long it takes for half of a dose to be removed from your body. It typically ... Citalopram, escitalopram, fluoxetine and sertraline all have long half-lives (see table above: Half-lives and time to almost complete elimination - SSRIs). If ... Apr 1, 2020 ... SSRIs like Paxil (paroxetine), which has a half-life of about one day, should be tapered down over a longer period than drugs like Prozac ( ... Jul 1, 1997 ... ... half-life of fluoxetine and 7- to 9-day half-life of norfluoxetine. Bruising and bleeding disorders have also been described with fluoxetine use ... Jan 4, 2023 ... ... fluoxetine, while paroxetine is appetite ... Due to its short half-life, paroxetine is not optimal for patients who might miss a dose. When stopping antidepressant medication: - Consider the half-life of the antidepressant - those with a shorter half-life such as venlafaxine and paroxetine ... As might be predicted from its primary site of metabolism, liver impairment can affect the elimination of fluoxetine. The elimination half-life of fluoxetine ... Mar 29, 2025 ... Fluoxetine has a long half-life, which can be a concern in certain patient populations, particularly older adults, due to its potential for ... Relative bioavailability of each dose administered via the TD route was 10% of the value for oral administration of the drug. Mean plasma elimination half-life ...