Are there any specific concerns related to Prozac's long half-life in the context of anesthesia?

May 15, 2022 ... Antidepressant withdrawal symptoms ; Drug. Half out of body in. 99% out of body in ; Serotonin reuptake inhibitors ; paroxetine (Paxil). 24 hours. Jul 1, 1997 ... ... half-life of fluoxetine and 7- to 9-day half-life of norfluoxetine. Bruising and bleeding disorders have also been described with fluoxetine use ... Feb 28, 2024 ... Due to the drug's action on the reuptake of serotonin, fluoxetine produces an activating effect, and due to its long half-life, the initial ... Further, the elimination half life of it's active metabolite, norfluoxetine, ranges from 4-16 days after both acute and chronic administration. The half-life of ... The long elimination half-lives of fluoxetine and norfluoxetine assure that, even when dosing is stopped, active drug substance will persist in the body for ... Apr 26, 2022 ... Fluoxetine has a half-life of 1–4 days and proved to be effective in the maintenance treatment of major depression and anxiety disorders ... Jan 17, 2017 ... Fluoxetine has unique pharmacokinetic properties, probably what distinguishes fluoxetine from other SSRIs is its long half-life. Most SSRIs have ... Jan 1, 2022 ... Of the SSRIs, paroxetine and fluvoxamine have the shortest half-lives and therefore are associated with the highest risk. Citalopram, ... Apr 13, 2025 ... This compound has double the half-life of fluoxetine and has a half-life of anywhere from 4 to 15 days. It can take months for the body to get ... Hepatic. Elimination. Renal. Half-life (fluoxetine): 1–3 days (acute); 4–6 days (chronic) ...