What are the pharmacokinetic considerations when combining Prozac and alprazolam or clonazepam?

Discontinuation symptoms have been reported in association with selective serotonin reuptake inhibitors (SSRIs). Because of the long elimination half-life of ... May 3, 2022 ... It has a very long half-life (meaning it takes a long time for it to ... Infant blood levels of fluoxetine may reach more than half of maternal ... Flumazenil has a short half-life, so it may need to be repeated. Benzodiazepines should not be used to control CNS excitation, because a paradoxical ... Its mean terminal half–life after a single dose was 8.6 days and after multiple dosing was 9.3 days. Steady–state levels after prolonged dosing are similar to ... Jun 15, 2024 ... Most SSRIs have a half-life of approximately one day, but Prozac's half-life is four to six days.1 This is important because withdrawal symptoms ... Aug 12, 2022 ... This long half-life makes it easier to stop fluoxetine than some other antidepressants, which can cause withdrawal symptoms when you stop them ... A sensitivity analysis found that removing responses involving fluoxetine, which has an especially long half-life, did not significantly alter this result. Further, the elimination half life of it's active metabolite, norfluoxetine, ranges from 4-16 days after both acute and chronic administration. The half-life of ... Oct 17, 2013 ... The long elimination half-lives of fluoxetine and its principal metabolite, norfluoxetine, are of potential consequence when medicines are ... Hepatic. Elimination. Renal. Half-life (fluoxetine): 1–3 days (acute); 4–6 days (chronic) ...