What are the pharmacokinetic considerations when combining Prozac with a tricyclic antidepressant like clomipramine for OCD?

Feb 1, 2001 ... While it is true that fluoxetine's active metabolite has a half-life of up to 16 days, because of its low incidence of side effects compared ... It is established that both fluoxetine and norfluoxetine have very long half-lives of 4–6 days and 4–16 days, respectively. Additionally, it has been reported ... Hepatic. Elimination. Renal. Half-life (fluoxetine): 1–3 days (acute); 4–6 days (chronic) ... Feb 23, 2022 ... Half-life refers to how long it takes for half of the drug to be out of your system (regardless of how much you have in your system right now). Administering a drug less than once per day is generally not done, however. The ideal antidepressant would have a half-life consistent with once-a-day dosing or ... Dec 14, 2017 ... Fluoxetine (Prozac), which has a longer half-life compared to ... half-lives. As a result, methylene blue should generally not be given ... Further, the elimination half life of it's active metabolite, norfluoxetine, ranges from 4-16 days after both acute and chronic administration. The half-life of ... Sep 16, 2011 ... ... (Prozac), the risk of experiencing symptoms related to a decrease in the medication is low. That's because fluoxetine has a long half-life ... Jul 1, 1997 ... ... half-life of fluoxetine and 7- to 9-day half-life of norfluoxetine. Bruising and bleeding disorders have also been described with fluoxetine use ... Mar 24, 2025 ... Fluoxetine's long half-life is an advantage and a drawback. If fluoxetine works well, an occasional missed dose is not a problem; if problems ...