How do genetic polymorphisms in CYP enzymes affect individual responses to Prozac and its half-life?

Of the SSRIs, fluoxetine is generally not recommended for use in the elderly because of its long half-life and prolonged side effects. Paroxetine is also ... The half-life of its active metabolite, norfluoxetine, is about 7 to 9 days. Metabolism: Fluoxetine is extensively metabolized in the liver to a desmethyl ... The speed with which a specific antidepressant can be stopped is largely related to its half-life. Agents with very long half-lives, such as fluoxetine (half- ... Apr 24, 2023 ... • Drug half-lives can vary drastically. • Fluoxetine (Prozac) has a half-life of 4-6 days and has an active metabolite (norfluoxetine) that. If the drug's half-life is important to you. For example, if you are concerned about withdrawal effects and would prefer a drug with a longer half-life. For ... As might be predicted from its primary site of metabolism, liver impairment can affect the elimination of fluoxetine. The elimination half-life of fluoxetine ... Jan 17, 2024 ... ... half-life of 24 ± 2 h. However, the biological half-life of both fluoxetine and venlafaxine in the presence of L.stagnalis is unexplored. Oct 17, 2013 ... The long elimination half-lives of fluoxetine and its principal metabolite, norfluoxetine, are of potential consequence when medicines are ... PO, metabolized in the liver primarily by CYP2D6, with fluoxetine (parent drug) having a half life of several day half life of 1-4 days · norfluoxetine is an ... When stopping antidepressant medication: - Consider the half-life of the antidepressant - those with a shorter half-life such as venlafaxine and paroxetine ...