What withdrawal symptoms might occur after stopping Prozac, related to its long half-life?

Discontinuation symptoms have been reported in association with selective serotonin reuptake inhibitors (SSRIs). Because of the long elimination half-life of ... Fluoxetine (Prozac) used daily (B). Long half-life; agitation, insomnia, anorexia5. SSRI with shorter half-life (e.g., escitalopram. [Lexapro], sertraline [ ... May 15, 2022 ... Antidepressant withdrawal symptoms ; Drug. Half out of body in. 99% out of body in ; Serotonin reuptake inhibitors ; paroxetine (Paxil). 24 hours. Fluoxetine, sold under the brand name Prozac, among others, is an antidepressant ... "[Pharmacokinetics of SSRI antidepressants: half-life and clinical ... Apr 13, 2025 ... This compound has double the half-life of fluoxetine and has a half-life of anywhere from 4 to 15 days. It can take months for the body to get ... According to the FDA, the elimination half-life of fluoxetine is 1 to 3 days after acute administration, and 4 to 6 days after chronic administration, with its ... The speed with which a specific antidepressant can be stopped is largely related to its half-life. Agents with very long half-lives, such as fluoxetine (half- ... Paroxetine is also troublesome while fluoxetine rarely causes withdrawal symptoms. (especially if the dose is under 40 mg) due to the long half-life of the ... Feb 23, 2022 ... Half-life refers to how long it takes for half of the drug to be out of your system (regardless of how much you have in your system right now). As most SSRIs have a half-life of around 24 hours, skipping doses creates large changes to drug levels, and so increases the risk and/or severity of withdrawal.