What strategies can be used to minimize the risk of rebound depression when stopping Prozac?

The speed with which a specific antidepressant can be stopped is largely related to its half-life. Agents with very long half-lives, such as fluoxetine (half- ... Sep 16, 2011 ... ... (Prozac), the risk of experiencing symptoms related to a decrease in the medication is low. That's because fluoxetine has a long half-life ... Many people don't see them until a couple weeks after they've stopped taking Prozac because Prozac has a longer half-life than other antidepressants. As a ... Mar 29, 2025 ... Fluoxetine has a long half-life, which can be a concern in certain patient populations, particularly older adults, due to its potential for ... The half-life of Prozac is initially about one to three days, though with continued use, that extends to four to six days. The drug is 99 percent out of your ... Nov 7, 2022 ... Prozac's half-life is approximately two to six days but can be longer if the patient has used it for a long time. Apr 26, 2022 ... Fluoxetine has a half-life of 1–4 days and proved to be effective in the maintenance treatment of major depression and anxiety disorders ... Apr 21, 2025 ... Fluoxetine stays in your system longer (with a half-life of 2-7 days, depending on use patterns), resulting in Prozac withdrawal symptoms that ... Mar 24, 2025 ... Fluoxetine's long half-life is an advantage and a drawback. If fluoxetine works well, an occasional missed dose is not a problem; if problems ... May 31, 2024 ... Also, fluoxetine has a comparatively longer half-life (48-72 hours compared to 27-33 hours for escitalopram), resulting in a more prolonged ...