Can changes in protein binding alter the free concentration and apparent half-life of Prozac?

The elimination half-life of fluoxetine is 48–72 h, averaging almost 70 h. The half-life of norfluoxetine is 7–9 days. The elimination half-lives for both ... Discontinuation symptoms have been reported in association with selective serotonin reuptake inhibitors (SSRIs). Because of the long elimination half-life of ... May 15, 2022 ... Antidepressant withdrawal symptoms ; Drug. Half out of body in. 99% out of body in ; Serotonin reuptake inhibitors ; paroxetine (Paxil). 24 hours. Mar 29, 2025 ... Fluoxetine has a long half-life, which can be a concern in certain patient populations, particularly older adults, due to its potential for ... Its mean terminal half–life after a single dose was 8.6 days and after multiple dosing was 9.3 days. Steady–state levels after prolonged dosing are similar to ... May 31, 2024 ... Also, fluoxetine has a comparatively longer half-life (48-72 hours compared to 27-33 hours for escitalopram), resulting in a more prolonged ... Mar 24, 2025 ... Fluoxetine's long half-life is an advantage and a drawback. If fluoxetine works well, an occasional missed dose is not a problem; if problems ... Jul 1, 1997 ... ... half-life of fluoxetine and 7- to 9-day half-life of norfluoxetine. Bruising and bleeding disorders have also been described with fluoxetine use ... Withdrawal symptoms (also called antidepressant or SRI discontinuation syndrome) are unpleasant physical and mental effects from reducing the dose of or ... Jun 25, 2021 ... A randomized placebo-controlled clinical trial suggested that shorter half-life antidepressants may be at higher risk of withdrawal syndrome ...