What is the role of first-pass metabolism in the overall pharmacokinetics of Prozac, and how does it relate to bioavailability and half-life?

The long elimination half-lives of fluoxetine and norfluoxetine assure that, even when dosing is stopped, active drug substance will persist in the body for ... It is established that both fluoxetine and norfluoxetine have very long half-lives of 4–6 days and 4–16 days, respectively. Additionally, it has been reported ... Because fluoxetine and its major metabolite, norfluoxetine, have long half-lives, a 6-week washout inter- val should be observed following discontinuation ... As might be predicted from its primary site of metabolism, liver impairment can affect the elimination of fluoxetine. The elimination half-life of fluoxetine ... Citalopram, escitalopram, fluoxetine and sertraline all have long half-lives (see table above: Half-lives and time to almost complete elimination - SSRIs). If ... Fluoxetine (Prozac) used daily (B). Long half-life; agitation, insomnia, anorexia5. SSRI with shorter half-life (e.g., escitalopram. [Lexapro], sertraline [ ... Jul 1, 1997 ... ... half-life of fluoxetine and 7- to 9-day half-life of norfluoxetine. Bruising and bleeding disorders have also been described with fluoxetine use ... Jun 17, 2014 ... Question: The antidepressant fluoxetine (or Prozac) has a half-life of about 3 days What percentage of a dose remains in the body after a day? Sep 12, 2024 ... Serotonin syndrome often resolves within 24 hours of discontinuing the serotonergic agent and initiating care, but drugs with long half-lives or ... Half-life: 4-6 days (chronic administration); 1-3 days (acute); 7-6 days (cirrhosis). Dialyzable: No. Excretion: Urine (15%). Pharmacogenomics. Several SSRIs ...