What factors can cause inter-individual variability in the AUC of Prozac?

The elimination half-life of fluoxetine is 48–72 h, averaging almost 70 h. The half-life of norfluoxetine is 7–9 days. The elimination half-lives for both ... The long half-life of the drug and its metabolite contribute to a 4-week period to reach steady-state concentrations. As with all available antidepressants ... Jun 27, 2018 ... The half-life of Fluoxetine is about 2 to 7 days; however, norfluoxetine lasts longer with a half-life of 4 to 15 days. Fluoxetine stays in the ... Hepatic. Elimination. Renal. Half-life (fluoxetine): 1–3 days (acute); 4–6 days (chronic) ... Jan 17, 2024 ... ... half-life of 24 ± 2 h. However, the biological half-life of both fluoxetine and venlafaxine in the presence of L.stagnalis is unexplored. ... fluoxetine's long half-life. (compared to other antidepressants that can be washed out more quickly). ⦁ Also due to long half-life, effects of dose changes ... Jun 25, 2021 ... A randomized placebo-controlled clinical trial suggested that shorter half-life antidepressants may be at higher risk of withdrawal syndrome ... The speed with which a specific antidepressant can be stopped is largely related to its half-life. Agents with very long half-lives, such as fluoxetine (half- ... Jan 12, 2024 ... Despite its long-half life, symptoms associated with the discontinuation of PROZAC have been reported in clinical trials and post-marketing ... Jun 17, 2014 ... Question: The antidepressant fluoxetine (or Prozac) has a half-life of about 3 days What percentage of a dose remains in the body after a day?