What are the potential advantages of drug accumulation in the context of antidepressant treatment?

Fluoxetine, sold under the brand name Prozac, among others, is an antidepressant ... "[Pharmacokinetics of SSRI antidepressants: half-life and clinical ... Feb 17, 2023 ... Fluoxetine may still cause medicine interactions 5 or 6 weeks after stopping as fluoxetine and its active metabolite have a long half-life. May 23, 2022 ... The half-life of a drug is an estimate of the time it takes for the concentration or amount in the body of that drug to be reduced by exactly one-half (50%). A sensitivity analysis found that removing responses involving fluoxetine, which has an especially long half-life, did not significantly alter this result. Further, the elimination half life of it's active metabolite, norfluoxetine, ranges from 4-16 days after both acute and chronic administration. The half-life of ... These studies suggest that fluoxetine has a long half-life, which contributes to its steady presence in the bloodstream, potentially leading to fewer side ... The half-life of a medication is relevant to understanding its effects and potential withdrawal symptoms. Fluoxetine has a half-life of approximately 4-6 days. Aug 2, 2022 ... Then wait perhaps 1, 2, or more weeks for things to settle before the next cut. Expect withdrawal symptoms to emerge around the drug's half-life ... Jan 5, 2020 ... For many people, antidepressants can be literal lifesavers. But not everyone wants to stay on them indefinitely, and herein lies the problem: ... Sep 16, 2011 ... ... (Prozac), the risk of experiencing symptoms related to a decrease in the medication is low. That's because fluoxetine has a long half-life ...