Can the half-life of Prozac vary between individuals?

May 23, 2022 ... The half-life of a drug is an estimate of the time it takes for the concentration or amount in the body of that drug to be reduced by exactly one-half (50%). Fluoxetine (Prozac) used daily (B). Long half-life; agitation, insomnia, anorexia5. SSRI with shorter half-life (e.g., escitalopram. [Lexapro], sertraline [ ... The long elimination half-lives of fluoxetine and norfluoxetine assure that, even when dosing is stopped, active drug substance will persist in the body for ... Its mean terminal half–life after a single dose was 8.6 days and after multiple dosing was 9.3 days. Steady–state levels after prolonged dosing are similar to ... The elimination half-life of fluoxetine is about 1 to 4 days, while that of its metabolite norfluoxetine ranges from 7 to 15 days. Fluoxetine has a nonlinear ... Many people don't see them until a couple weeks after they've stopped taking Prozac because Prozac has a longer half-life than other antidepressants. As a ... PO, metabolized in the liver primarily by CYP2D6, with fluoxetine (parent drug) having a half life of several day half life of 1-4 days · norfluoxetine is an ... May 11, 2020 ... ... fluoxetine profile. In fact, due its long half-life and to the time required to induce changes at serotonergic receptor levels, fluoxetine ... The speed with which a specific antidepressant can be stopped is largely related to its half-life. Agents with very long half-lives, such as fluoxetine (half- ... The good effects of fluoxetine may, after a while, improve your sex life as your mood lifts and you become interested in life and relationships again. Some ...