What are the active metabolites of Prozac and what are their half-lives?

According to the FDA, the elimination half-life of fluoxetine is 1 to 3 days after acute administration, and 4 to 6 days after chronic administration, with its ... Aug 1, 2016 ... Because Prozac's half-life is longer than Lexapro's, it takes longer to go through your body. Seniors tend to process drugs more slowly. A ... PO, metabolized in the liver primarily by CYP2D6, with fluoxetine (parent drug) having a half life of several day half life of 1-4 days · norfluoxetine is an ... In general, manufacturers advise caution (prolonged half-life). Hepatic impairment For fluoxetine. Dose adjustments. Manufacturer advises dose reduction or ... Jan 12, 2024 ... Despite its long-half life, symptoms associated with the discontinuation of PROZAC have been reported in clinical trials and post-marketing ... Oct 17, 2013 ... The long elimination half-lives of fluoxetine and its principal metabolite, norfluoxetine, are of potential consequence when medicines are ... Jun 17, 2014 ... Question: The antidepressant fluoxetine (or Prozac) has a half-life of about 3 days What percentage of a dose remains in the body after a day? Sep 12, 2024 ... Serotonin syndrome often resolves within 24 hours of discontinuing the serotonergic agent and initiating care, but drugs with long half-lives or ... May 18, 2017 ... ... SSRI paroxetine, has been linked with a small increased risk in birth defects. Fluoxetine has a long half-life, which means it stays longer ... Because fluoxetine and its major metabolite, norfluoxetine, have long half-lives, a 6-week washout inter- val should be observed following discontinuation ...