How does the long half-life of Prozac influence its effects on the liver?

Jun 27, 2018 ... The half-life of Fluoxetine is about 2 to 7 days; however, norfluoxetine lasts longer with a half-life of 4 to 15 days. Fluoxetine stays in the ... If the drug's half-life is important to you. For example, if you are concerned about withdrawal effects and would prefer a drug with a longer half-life. For ... Jun 15, 2024 ... Most SSRIs have a half-life of approximately one day, but Prozac's half-life is four to six days.1 This is important because withdrawal symptoms ... Jan 1, 2022 ... Of the SSRIs, paroxetine and fluvoxamine have the shortest half-lives and therefore are associated with the highest risk. Citalopram, ... The half-life of its active metabolite, norfluoxetine, is about 7 to 9 days. Metabolism: Fluoxetine is extensively metabolized in the liver to a desmethyl ... The elimination half-life of fluoxetine is 48–72 h, averaging almost 70 h. The half-life of norfluoxetine is 7–9 days. The elimination half-lives for both ... Sep 9, 2005 ... Although many women may believe that they are only getting a drug effect during the time they are actually taking fluoxetine, the half life of ... Fluoxetine (brand names: Prozac®, Reconcile®, Sarafem®) is an SSRI (selective serotonin reuptake inhibitor) antidepressant used to treat a variety of ... Its mean terminal half–life after a single dose was 8.6 days and after multiple dosing was 9.3 days. Steady–state levels after prolonged dosing are similar to ... Mar 24, 2025 ... Fluoxetine's long half-life is an advantage and a drawback. If fluoxetine works well, an occasional missed dose is not a problem; if problems ...