How does the long half-life of Prozac affect the likelihood of rebound depression upon discontinuation?

Jan 12, 2024 ... Despite its long-half life, symptoms associated with the discontinuation of PROZAC have been reported in clinical trials and post-marketing ... Oct 17, 2013 ... The long elimination half-lives of fluoxetine and its principal metabolite, norfluoxetine, are of potential consequence when medicines are ... Apr 3, 2023 ... The half-life of Prozac is longer than that of Zoloft. If you miss a dose or stop taking either antidepressant medication abruptly, the effects ... Sep 17, 2024 ... Although Prozac has a longer half-life than some other SSRIs, meaning it stays in the body longer, suddenly stopping the medication can still ... According to the FDA, the elimination half-life of fluoxetine is 1 to 3 days after acute administration, and 4 to 6 days after chronic administration, with its ... Jun 15, 2024 ... Most SSRIs have a half-life of approximately one day, but Prozac's half-life is four to six days.1 This is important because withdrawal symptoms ... Jun 27, 2019 ... These include fluoxetine (aka Prozac), paroxetine (aka Paxil) ... half life of 20-100 hours). These can be highly addictive. These are ... May 3, 2022 ... It has a very long half-life (meaning it takes a long time for it to ... Infant blood levels of fluoxetine may reach more than half of maternal ... Jun 27, 2018 ... The half-life of Fluoxetine is about 2 to 7 days; however, norfluoxetine lasts longer with a half-life of 4 to 15 days. Fluoxetine stays in the ... 1 The half- lives of sertraline and fluoxetine in dogs are 26 and 20 hours, respectively.8 The half-life of paroxetine is 20 hours, but it increases in ...