How does the concept of area under the curve (AUC) relate to the half-life and overall drug exposure with Prozac treatment?

Oct 17, 2013 ... The long elimination half-lives of fluoxetine and its principal metabolite, norfluoxetine, are of potential consequence when medicines are ... May 23, 2022 ... The half-life of a drug is an estimate of the time it takes for the concentration or amount in the body of that drug to be reduced by exactly one-half (50%). Feb 24, 2022 ... It will take longer to leave the body completely. Specifically, it can take around 25 days or more for Prozac to leave your system. May 15, 2022 ... Antidepressant withdrawal symptoms ; Drug. Half out of body in. 99% out of body in ; Serotonin reuptake inhibitors ; paroxetine (Paxil). 24 hours. Jan 12, 2023 ... Prozac has a half-life that can range from 1-3 days depending on the amount of time the individual was on the drug. Longer-term usage of Prozac ... When stopping antidepressant medication: - Consider the half-life of the antidepressant - those with a shorter half-life such as venlafaxine and paroxetine ... Its mean terminal half–life after a single dose was 8.6 days and after multiple dosing was 9.3 days. Steady–state levels after prolonged dosing are similar to ... Mar 29, 2025 ... Fluoxetine has a long half-life, which can be a concern in certain patient populations, particularly older adults, due to its potential for ... Jun 25, 2021 ... A randomized placebo-controlled clinical trial suggested that shorter half-life antidepressants may be at higher risk of withdrawal syndrome ... Sep 17, 2024 ... Although Prozac has a longer half-life than some other SSRIs, meaning it stays in the body longer, suddenly stopping the medication can still ...