How can understanding the half-life of Prozac inform the timing of blood draws for therapeutic drug monitoring?

Feb 19, 2008 ... Fluoxetine, marketed under the brand name Prozac ... The period is longer in the former incidence because of the long half-life of fluoxetine in ... The speed with which a specific antidepressant can be stopped is largely related to its half-life. Agents with very long half-lives, such as fluoxetine (half- ... Apr 1, 2020 ... SSRIs like Paxil (paroxetine), which has a half-life of about one day, should be tapered down over a longer period than drugs like Prozac ( ... In general, manufacturers advise caution (prolonged half-life). Hepatic impairment For fluoxetine. Dose adjustments. Manufacturer advises dose reduction or ... The elimination half-life of fluoxetine is about 1 to 4 days, while that of its metabolite norfluoxetine ranges from 7 to 15 days. Fluoxetine has a nonlinear ... Apr 17, 2023 ... Prozac works by inhibiting the reuptake of serotonin, allowing it to stay in the brain for longer periods and enhancing its effects. Jul 1, 1997 ... ... half-life of fluoxetine and 7- to 9-day half-life of norfluoxetine. Bruising and bleeding disorders have also been described with fluoxetine use ... Oct 1, 2019 ... Percentage remaining after one day: We can use the formula for exponential decay, which is: Remaining Percentage = 100 * (1/2)(time/half-life). Mar 6, 2021 ... Pharmacokinetics of Fluoxetine ; Primarily eliminated via hepatic metabolism to inactive metabolites, which are then excreted by the kidney. · 1 ... Jun 1, 2016 ... Five half-lives equates to about five days for most SSRIs except fluoxetine, which can still be significantly active five or more weeks after ...