Can miRNAs be used to modulate EGFR expression for therapeutic purposes?

EGFR possesses kinase-independent (KID) pro-survival functions in cancer cells. This new knowledge has offered a different angle of understanding of EGFR in ... Jan 22, 2025 ... EGFR-positive lung cancer represents about 10-15% of lung cancers in the United States and most often appears in the adenocarcinoma subtype of non-small cell ... Dec 4, 2019 ... A phase 3 trial compared first-line osimertinib with other EGFR-TKIs in patients with EGFR mutation–positive advanced non–small-cell lung cancer (NSCLC). A mutation in the EGFR gene can be found in some people who have been diagnosed with non-small cell lung cancer (NSCLC). NSCLC with an EGFR mutation is known as ... Mar 12, 2024 ... Is it good to have a high glomerular filtration rate? A GFR of 90 or higher is considered normal if you're healthy unless you have other ... EGFR tyrosine kinase inhibitors (EGFR TKIs) block EGFR from working, which stops or slows the growth of cancer cells. They are taken as pills. EGFR TKIs are ... Sep 20, 2022 ... Race-based eGFR values. Glomerular filtration rate (GFR) is a measure of how fast a person's kidneys are filtering waste and excess water from ... Jan 19, 2015 ... eGFR takes into account the serum creatinine value and also patient ... For CT, eGFR > 45 indicates no increased risk of kidney damage from ... One kidney number to check: eGFR · What is eGFR? · eGFR tests measure your level of kidney function—from normal kidney function to kidney failure. An eGFR of less ... EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell ...