What were the landmark studies that led to the development of EGFR inhibitors?

Mar 12, 2024 ... Is it good to have a high glomerular filtration rate? A GFR of 90 or higher is considered normal if you're healthy unless you have other ... Apr 5, 2021 ... What is EGFR-mutant lung cancer? A mutation in the gene EGFR, which stands for epidermal growth factor receptor, causes cells to grow without ... Your eGFR isn't the only thing you and your doctor will look at in deciding when you should start dialysis. You will also consider: Whether you have swelling, ... EGFRvIII displays low-level constitutive signaling that is augmented by reduced internalization and downregulation. Aberrant EGFRvIII signaling has been shown ... Jan 22, 2025 ... EGFR-positive lung cancer represents about 10-15% of lung cancers in the United States and most often appears in the adenocarcinoma subtype of non-small cell ... Protein names · Recommended name. Epidermal growth factor receptor. Curated · EC number. EC:2.7.10.1 (UniProtKB | ENZYME | Rhea ) · Alternative names. Proto- ... Jun 24, 2024 ... The eGFR blood test will indicate how well the kidneys are functioning by measuring the kidneys' ability to filter toxins or waste from your ... Apr 23, 2020 ... eGFR or Calculated Creatinine Clearance is a simple test to detect early changes in kidney function. A normal result means that kidney disease ... eGFR measures your kidneys' ability to filter toxins or waste from your blood. A very low number may indicate kidney failure, which requires dialysis or a ... Aug 30, 2021 ... Importance Using the same level of estimated glomerular filtration rate (eGFR) to define chronic kidney disease (CKD) regardless of patient age ...