How does the metabolic state of the cell impact DNA replication and repair processes?

Then, at a critical point during interphase (called the S phase), the cell duplicates its chromosomes and ensures its systems are ready for cell division. If ... Actively dividing eukaryote cells pass through a series of stages known collectively as the cell cycle: two gap phases (G1 and G2); an S (for synthesis) ... Jan 22, 2003 ... Vascular endothelial cell (VEC) proliferation is a key event in angiogenesis and is tightly regulated. Electric potential differences exist ... The 5-bromo-2′-deoxyuridine (BrdU) labeling of cells followed by antibody staining has been the standard method for direct measurement of cells in the ... During interphase, G1 involves cell growth and protein synthesis, the S phase ... phase, of interphase during which DNA replication occurs. telophase: the ... Dec 6, 2022 ... During the G1 phase, also known as the first gap phase, the cell becomes physically larger, copies organelles, and produces the molecular ... It is generally believed that this type of repair occurs preferentially in the late S, G2 and M phases of the cell cycle, when the sister chromatid is ... During G1 phase, growth-dependent cyclin-dependent kinase (CDK) activity promotes DNA replication and initiates G1-to-S phase transition. In fact, the accumulation of cells in S phase was found to be a gradual process that occurs over several cell cycles, as shown in Fig. 2 B for ... May 29, 2015 ... We present a tool to identify cell cycle phases and in particular, sub-stages of the DNA replication phase (S-phase) based on the characteristic patterns of ...