What are the potential links between defects in DNA replication and the development of autoimmune diseases?

Dec 6, 2022 ... During the G1 phase, also known as the first gap phase, the cell becomes physically larger, copies organelles, and produces the molecular ... Oct 7, 2014 ... ... cells were in G0/G1 phase under physiological conditions (Fig. 1C). There were no significant differences in cell cycle status (G0/G1, S ... Then, at a critical point during interphase (called the S phase), the cell duplicates its chromosomes and ensures its systems are ready for cell division. If ... Members of the Bcl-2 family play a major role in the patho-biology of head and neck cancer ... cycle and survival of endothelial cells and HNSCC and on the ... Two gap phases precede the S and M phases; in G1 the cell prepares for DNA synthesis, and in G2 the cell prepares for the mitotic division that takes place in ... Aug 14, 2008 ... In this study, we show that miR-17-92 is a cell cycle regulated locus, and ectopic expression of a single microRNA (miR-17-5p) is sufficient to ... Sep 12, 2024 ... During S phase, DNA synthesis occurs in preparation for subsequent rounds of cell division. A small molecule called 2[[3-(2,3-dichlorophenoxy) ... Background & Aims: The G1/S-phase controlling mechanism known as the RB pathway is commonly deregulated in human malignancies. Here, the abundance and ... Apr 1, 2019 ... We show here that small molecule 2-[(3,4-dihydroquinolin-1(2H)-yl)(p-tolyl)methyl]phenol (THTMP), a potential anticancer agent, increases the human ... If a mutation occurs in a protein that regulates the cell cycle, e.g. p53 ... In which phase of the cell cycle is DNA replicated? G1 phase. S phase. G2 ...