How can we selectively target the S phase of cancer cells while sparing normal cells?

What occurs during the S phase of the cell cycle? 1) the genetic material is copied, 2) chromosomes replicate and become double stranded chromatids. Figure 1: A cell moves through a series of phases in an orderly manner. During interphase, G1 involves cell growth and protein synthesis, the S phase involves ... Mar 11, 2019 ... The cell cycle occurs over approximately 24 hours (in a typical human cell) and in two distinct stages: interphase, which includes three phases ... Members of the Bcl-2 family play a major role in the patho-biology of head and neck cancer ... cycle and survival of endothelial cells and HNSCC and on the ... Aug 31, 2020 ... ... S phase cell cycle block via p21 upregulation. In: Immunity, inflammation and disease. 2020 ; Vol. 8, No. 4. pp. 568-583. @article ... S phase (Synthesis; when the copying of DNA happens). ... These attack cancer cells during specific phases of the cell cycle, but never during the resting phase. During G1 phase, growth-dependent cyclin-dependent kinase (CDK) activity promotes DNA replication and initiates G1-to-S phase transition. Dec 6, 2022 ... During the G1 phase, also known as the first gap phase, the cell becomes physically larger, copies organelles, and produces the molecular ... Jul 8, 2008 ... Cyclin D/CDdk4–Cdk6 activity occurs in mid-late G1 phase, upstream of Cdk2/cyclin E activity. Under conditions favouring proliferation, the ... There are standard modeling algorithms that can then be employed to determine the breakdown of cells in the G0/G1 phase versus S phase, G2, or polyploidy state ...