How can research on stereocilia lead to improved diagnostics and treatments for hearing and balance disorders?

Mar 13, 2020 ... When stereocilia become damaged, they do not regenerate, and sensorineural hearing loss is the result. While there are no surgeries that can ... Jul 22, 2024 ... We conclude that stereocilia fusion is linked with the failure to maintain cellular proteostasis and with disturbances in stereociliary calcium balance. Sep 8, 2022 ... Stereocilia transform audio waves of sound into electrical impulses ... Our cells rely on a healthy supply of blood throughout our body, and this ... Jul 18, 2022 ... Espins are actin-bundling proteins that have a well-characterized role in stereocilia formation; loss of function mutations in Espin result in ... Jan 21, 2021 ... Abstract. Inner ear hair cells detect sound-induced displacements and transduce these stimuli into electrical signals in a hair bundle that ... This article obtains the stereocilia movement generated by basilar membrane (BM) vibration based on the positional relationship between the various structures ... Jan 4, 2021 ... show that ADF/cofilin-1 are recruited to mechanotransducing auditory stereocilia tips, where they increase the availability of F-actin barbed. Jun 11, 2019 ... ... stereocilia. The stereocilia within the same hair bundle have differing lengths. They are aligned in an orderly way to form a wedge shape ... May 21, 2018 ... These tiny fibers form bundles sitting atop sensory hair cells deep inside your inner ear, and give them their name. Stereocilia are as ... PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing. Nature Comm. 10: 3801. 153. György, B., Nist-Lund, C., Pan, B., Asai ...