What are the challenges in developing therapies for stereocilia damage?

Aug 23, 2016 ... Abstract. Stereocilia are actin-based protrusions on auditory and vestibular sensory cells that are required for hearing and balance. They ... Apr 13, 2017 ... Because the actin filaments in the stereocilia of hair borders still remain as compact bun- dles, albeit very disordered, there must be an addi-. Sep 8, 2022 ... Stereocilia transform audio waves of sound into electrical impulses ... Our cells rely on a healthy supply of blood throughout our body, and this ... Jun 20, 2019 ... We report that TRIOBP-5 is essential for thickening bundles of F-actin in rootlets, establishing their mature dimensions and for stiffening supporting cells. ... stereocilia of regimented lengths and a single microtubule-based kinocilium. ... We have developed a large-scale purification method that enriches stereocilia ... Feb 9, 2022 ... These cells possess stereocilia connected to the tectorial membrane. ... During auditory stimulation, sound waves in the cochlea cause deflection ... Jun 11, 2013 ... Stereocilia are bundles of bristly projections that extend from the tops of sensory cells, called hair cells, in the inner ear. Each stereocilia ... Jan 25, 2016 ... ... stereocilia. While functionally very different, the protein complexes that organize microvilli and stereocilia have striking parallels. Both ... Mar 11, 2019 ... The tip links are connected to stretch-activated cation channels on the tips of the stereocilia. When a sound wave vibrates the basilar membrane ... ... stereocilia functional architecture and self-renewal. Rzadzinska AK 1 ,. Schneider ME ,. Davies C ,. Riordan GP ,. Kachar B. Author information. Affiliations. 1 ...