How might stereocilia be affected in individuals with Meniere's disease?

Male Smpx null mice showed a progressive hearing loss starting from high frequency at the 3rd month. Hearing loss in female mice was milder and occurred later. ... stereocilia? How did the authors explain inconsistencies with previous published results by Ohmori? c) What was the nature of the evidence that transduction ... PKHD1L1 is a coat protein of hair-cell stereocilia and is required for normal hearing. Nature Comm. 10: 3801. 153. György, B., Nist-Lund, C., Pan, B., Asai ... ... stereocilia functional architecture and self-renewal. Rzadzinska AK 1 ,. Schneider ME ,. Davies C ,. Riordan GP ,. Kachar B. Author information. Affiliations. 1 ... Jun 20, 2019 ... We report that TRIOBP-5 is essential for thickening bundles of F-actin in rootlets, establishing their mature dimensions and for stiffening supporting cells. Deflection of the bundle of stereocilia is mechanically responsible for stretching ion pores in the stereocilia, allowing a cation current to pass into the cell ... This article obtains the stereocilia movement generated by basilar membrane (BM) vibration based on the positional relationship between the various structures ... ... stereocilia of regimented lengths and a single microtubule-based kinocilium. ... We have developed a large-scale purification method that enriches stereocilia ... Jan 25, 2016 ... ... stereocilia. While functionally very different, the protein complexes that organize microvilli and stereocilia have striking parallels. Both ... Mar 28, 2017 ... Mechanotransducer channels at the tips of sensory stereocilia of inner ear hair cells are gated by the tension of 'tip links' ...