How can mathematical modeling enhance our understanding of stereocilia mechanics?

Mar 13, 2020 ... When stereocilia become damaged, they do not regenerate, and sensorineural hearing loss is the result. While there are no surgeries that can ... Jul 18, 2022 ... Espins are actin-bundling proteins that have a well-characterized role in stereocilia formation; loss of function mutations in Espin result in ... Male Smpx null mice showed a progressive hearing loss starting from high frequency at the 3rd month. Hearing loss in female mice was milder and occurred later. We previously reported that CIB2 binds to WHRN and is essential for stereocilia staircase architecture of cochlear hair cells. Here, we refine the ... ... stereocilia bathing in the surrounding endolymph. The cell body itself is localised in the perilymph compartment (see transverse section of the organ of ... the stereocilia and in the epithelial lining of the first segment of the ductus epididymidis in mice by Becker and McEnery. (1966). The function of the ... Jan 4, 2021 ... show that ADF/cofilin-1 are recruited to mechanotransducing auditory stereocilia tips, where they increase the availability of F-actin barbed. Jun 3, 2019 ... Noise-induced hearing loss happens when tiny hair-like structures (stereocilia) that sit on top of hair cells in the inner ear are damaged by noises that are ... Mar 11, 2019 ... The tip links are connected to stretch-activated cation channels on the tips of the stereocilia. When a sound wave vibrates the basilar membrane ... May 24, 2023 ... Stereocilia are miniscule hair-like protrusions on the surface of sensory cells (also called hair cells) found deep within the cochlear and ...