What are the mechanisms of ototoxicity associated with different drugs?

Jul 22, 2024 ... We conclude that stereocilia fusion is linked with the failure to maintain cellular proteostasis and with disturbances in stereociliary calcium balance. Apr 21, 2025 ... Cilia are made of microtubules, while stereocilia and microvilli are made of actin filaments. The shortest is microvilli, intermediate height ... The actin filament bundle, which is held together by specific crossbridges, gives rigidity and exact dimensions to each stereocilium. The cuticular plate ... Aug 23, 2016 ... Abstract. Stereocilia are actin-based protrusions on auditory and vestibular sensory cells that are required for hearing and balance. They ... These results suggest that regulation of stereocilia length occurs through EPS8 and that CDH23 and PCDH15 regulate stereocilia lengthening beyond their role in ... ... stereocilia. These stereocilia are grouped into hair bundles, and the stereocilia in each hair bundle work together to facilitate the conversion of physical ... ... stereocilia of regimented lengths and a single microtubule-based kinocilium. ... We have developed a large-scale purification method that enriches stereocilia ... Mar 13, 2020 ... When stereocilia become damaged, they do not regenerate, and sensorineural hearing loss is the result. While there are no surgeries that can ... They have more stereocilia and long stereocilia relative to kinocilia heights. Tip link tensions show parallel behavior in peripheral columns of the bundle ... Feb 9, 2022 ... These cells possess stereocilia connected to the tectorial membrane. ... During auditory stimulation, sound waves in the cochlea cause deflection ...