What are the challenges in blinding participants and providers in trials evaluating objective measures of physical function?

Eligibility Requirements. Inclusion Criteria. Subjects must meet all the following criteria for enrollment in the study: - Eastern Cooperative Oncology Group ... An open-label randomised-controlled trial of azathioprine vs. mycophenolate mofetil for the induction of remission in treatment-naive autoimmune hepatitis. We describe two randomised trials where blinded outcome assessment was not possible, and discuss the strategies used to reduce the possibility of bias. Transcranial Focused Ultrasound (tFUS) offers a non-invasive method to modulate brain activity with high spatial precision, targeting thalamic nuclei associated ... This prospective, open-label clinical trial aimed to evaluate the tolerability and the efficacy of B cell depletion for remission induction in IgG4-RD. The Lancet Publishes Data from Phase 2, Open-Label Trial of Spinraza (Nusinersen) in Infants ... Today, Lancet published results from the Phase 2, open-label ... Acthar® Gel (repository corticotropin injection) is FDA-approved for treatment of acute episodes or exacerbation of PsA, but no clinical trials have ... Mar 2, 2018 ... An open label trial of folate receptor-targeted intraoperative molecular imaging to localize pulmonary squamous cell carcinomas. Jarrod D ... Mar 31, 2022 ... Different trial designs can be used by clinical researchers, with open-label trials one such design. This article will discuss what open-label trials are. May 2, 2023 ... A phase II open-label trial of avelumab plus axitinib in previously treated non-small-cell lung cancer or treatment-naïve, cisplatin ...