What are the implications of treatment switching in an open-label trial?

We describe two randomised trials where blinded outcome assessment was not possible, and discuss the strategies used to reduce the possibility of bias. Oct 2, 2010 ... Methods. We undertook an open-label randomised phase 3 trial in men with metastatic castration-resistant prostate cancer who had received ... This is a phase 2/3 open-label trial to evaluate the long-term safety, tolerability, and efficacy of sibeprenlimab administered subcutaneously (SC) in subjects ... Jan 1, 2025 ... This open-label study suggests efficacy and safety of psilocybin in severe TRD and supports further study of psychedelics in this population. Jun 17, 2023 ... Treatment with amikacin liposome inhalation suspension (ALIS) improve culture conversion in patients with M abscessus pulmonary disease. Open-Label Trial pronounce term ... A type of clinical trial. In open-label trials, both the researchers and participants know which drug (or other intervention) ... PROSPECTIVE NON-RANDOMIZED OPEN LABEL TRIAL COMPARING OUTCOME OF OPEN VERSUS ROBOTIC PEDIATRIC KIDNEY TRANSPLANT AT SINGLE CENTRE ... Introduction: Kidney ... Apr 8, 2014 ... Multicentre, Randomised, Open-Label Trial To Compare Efficacy And Tolerance Of Prednisone And IVIG In Patients With CIDP On A One Year Follow Up ... Study protocol; Open access; Published: 23 June 2020. ENG-releasing subdermal implants in postpartum teenagers – an open-label trial study protocol. Search Clinical Trials ; GOG-3112 (DESTINY-Ovarian01) · A Phase 3, Open-label, Multicenter, Randomized Trial of Trastuzumab Deruxtecan with Bevacizumab Versus ...