How can methodological advancements improve the rigor of open-label trials?

PROSPECTIVE NON-RANDOMIZED OPEN LABEL TRIAL COMPARING OUTCOME OF OPEN VERSUS ROBOTIC PEDIATRIC KIDNEY TRANSPLANT AT SINGLE CENTRE ... Introduction: Kidney ... We describe two randomised trials where blinded outcome assessment was not possible, and discuss the strategies used to reduce the possibility of bias. Jan 1, 2025 ... This open-label study suggests efficacy and safety of psilocybin in severe TRD and supports further study of psychedelics in this population. Jul 9, 2021 ... Phase 1b open-label trial of afatinib plus Xentuzumab (BI 836845) in patients with EGFR mutation-positive NSCLC after progression on EGFR tyrosine kinase ... The Lancet Publishes Data from Phase 2, Open-Label Trial of Spinraza (Nusinersen) in Infants ... Today, Lancet published results from the Phase 2, open-label ... Treating Foot Infections in Diabetic Patients: A Randomized, Multicenter, Open-Label Trial of Linezolid versus Ampicillin-Sulbactam/Amoxicillin-Clavulanate. Apr 8, 2013 ... The study was designed to evaluate the effects of minocycline treatment on markers of neuroinflammation and autism symptomatology in children with autism Search Clinical Trials ; GOG-3112 (DESTINY-Ovarian01) · A Phase 3, Open-label, Multicenter, Randomized Trial of Trastuzumab Deruxtecan with Bevacizumab Versus ... Nov 9, 2023 ... Conclusions. These findings suggest that prescribed medical cannabis may have minimal acute impact on cognitive function among patients with ... (143) - Multicenter Open-Label Trial Evaluating the Safety, Tolerability, Efficacy and Pharmacokinetics (PK) of Tacrolimus Inhalational Powder as a Replacement ...