How can computational models be used to predict the effects of different manipulations on hyperpolarization?

Mar 17, 2020 ... Here we reverse the voltage dependence of HCN channels by mutating only two residues located at the interface between the voltage sensor and the pore domain. Hyperpolarized 13 C magnetic resonance spectroscopic (MRS) imaging has emerged as a complementary metabolic imaging approach. Transportation of nuclear magnetization through nuclear spin diffusion accelerates when the system is hyperpolarized. ... Hyperpolarization in Diamond." Their method of achieving high nuclear polarization was established at room temperatur. Earlier this year, researchers at the ... Nuclear Magnetic Resonance (NMR) is a technique which uses the fact that the nuclei of many atoms act as tiny radiotransmitters, emitting radio signals at ... Oct 5, 2024 ... hyperpolarization: A phase where some potassium channels remain open and sodium channels reset. depolarization: Also called the rising phase, ... The finding that cAMP facilitates activation of HCN channels by affecting their voltage dependence suggests that the gating mechanism operated by ... Apr 4, 2022 ... Apparently the sodium potassium pump restores it following hyperpolarization, but I really can't imagine how it would do that! This article reviews the latest studies concerning the characterization of endothelium-derived hyperpolarizing factors, the mechanisms of factor release and ... Dec 26, 2023 ... Hyperpolarized 13 C MRI/S allows real-time metabolic changes to be observed non-invasively in living organisms, including cells, tissues, animal models, and ...