Can understanding hyperpolarization lead to new treatments for neurological disorders?

Hyperpolarization—that is, an increase in negative charge on the inside of the neuron—constitutes an inhibitory PSP, because it inhibits the neuron from firing ... Nov 12, 2024 ... ... hyperpolarization. Furthermore, once the sample is hyperpolarized, there is a risk that it could lose its magnetization during transport to ... hyperpolarization, but what is the mechanism by which pinacidil causes the hyperpolarization? As described by the Goldman [11] equation, the membrane ... Hyperpolarized fumarate is a promising biosensor for carbon-13 magnetic resonance metabolic imaging. Such molecular imaging applications require nuclear ... Hyperpolarization suggests an ideal contrast mechanism to highlight the ubiquitous and specific function of water in physiology, biology, and materials ... Hyperpolarized 13 C magnetic resonance spectroscopic (MRS) imaging has emerged as a complementary metabolic imaging approach. movement of a cell's membrane potential to a more negative value (i.e., movement further away from zero). When a neuron is hyperpolarized, it is less likely to ... Nov 16, 2021 ... ... hyperpolarization of the resting potential of the immediate firing motoneurons, even though we did not detect a measurable Ih at voltages ... hyperpolarized helium 3. A contrast agent composed of hyperpolarized helium He 3 gas (HP3He), with potential usage in diagnostic nuclear magnetic resonance (NMR)- ... Repolarization always leads first to hyperpolarization, a state in which the membrane potential is more negative than the default membrane potential. But soon ...