How can kinetic studies elucidate acylation mechanisms? What are Hammett plots and their application to acylation?

What is S-acylation? S-acylation is the post-translational addition of fatty acids to protein cysteine residues though a thioester bond. Importantly, and unlike ... Abstract. A Friedel-Crafts acylation of anisole with maleic anhydride promoted by aluminum chloride. The reaction goes at room temperature in 30 minutes and the ... Acylation ... In chemistry, acylation is a broad class of chemical reactions in which an acyl group (R−C=O) is added to a substrate. The compound providing the ... Jul 21, 2022 ... Results · K-Ras(G12S) is an oncogenic driver with GTPase activity · A β-lactone ligand acylates the mutant serine · Optimized β-lactone ligands ... May 17, 2018 ... In this post, we'll cover two important C–C bond-forming electrophilic aromatic substitution reactions which bear the names of their discoverers, Charles ... ... acylation. In this work we combine computational methods with experimental ... Acylation of the Endoplasmic Reticulum Chaperone Calnexin. PLoS Comput ... Sep 18, 2024 ... Acylation is a chemical reaction in which an acyl group (RCO-) is introduced into a molecule. The acyl group contains a carbonyl group (C=O) ... Investigating Interaction Dynamics of an Enantioselective Peptide Catalyzed Acylation Reaction. 26 April 2024, Version 1. Authors. Matthias Brauser · Author ... Acylation of Myelin Proteolipid Protein: A Link to the Past was published in The Roots of Modern Biochemistry on page 835. A novel bioluminescence-based method to investigate uptake of bile acids in living cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2018; 315:G529-G537