What are the regioselectivity considerations in acylation?

Jun 6, 2024 ... Deposition of histone acylations. Among the histone acyl marks, histone acetylation is the best studied. The distribution of histone acetylation ... Important reagents for acylation are acyl halides, carboxylic acids, anhydrides and ketenes. The alkyl group, R, in the acylating reagent can be an aryl or ... S-acylation, commonly known as S-palmitoylation, is a reversible posttranslational lipid modification in which fatty acid, usually palmitic acid, ... ASP is an adipocyte-derived protein which has potent anabolic effects on human adipose tissue for both glucose and free fatty acid (FFA) storage. Acylation is a reaction that transforms the amino group of amino acids into an amide using acid chlorides or acetic anhydrides as reagents, often in the ... ... acylation [11-13]. Indeed, a database of all known S-acylated proteins has ... acylation to become membrane associated. In some cases, this membrane ... Jul 21, 2022 ... Results · K-Ras(G12S) is an oncogenic driver with GTPase activity · A β-lactone ligand acylates the mutant serine · Optimized β-lactone ligands ... Friedel-Crafts Alkylation · Formation of a positively charged benzene ring. Two electrons are removed from the delocalised electron ring in benzene and used to ... A novel bioluminescence-based method to investigate uptake of bile acids in living cells. Am. J. Physiol. Gastrointest. Liver Physiol. 2018; 315:G529-G537 You can first prepare the corresponding aryl ketone by the Friedel-Crafts acylation and then reduce the carbonyl to the alkyl group.