What are the applications of acylation in nucleoside and nucleotide chemistry? What are acylated nucleobases?

Acylation is a common reaction in organic chemistry used to modify the chemical properties of a compound, such as increasing its reactivity or altering its ... Mar 22, 2025 ... The presence of a signal with hydroxylamine (+HA) treatment indicates that fatty acids are attached to the protein via a thioester bond. These ... Nov 2, 2020 ... O acylation is a type of acylation process in which the final product contains an oxygen atom, connecting the acyl group to the reactant ... Feb 9, 2023 ... ... acylation on human and monkey epithelial cells infected with SARS-CoV-2. Their findings were recently published in the Journal of Lipid ... demonstrated that N-terminal acylation by a C8-C10 chain positively affects the antimicrobial activity of compounds: modified peptides show rapid killing ... This reaction uses the acetyl chloride, CH3COCl, as the acylating agent and the compound called aluminium chloride, AlCl3 as the catalyst. In Friedel-Crafts ... Sep 20, 2023 ... ... acylation. The reactive electrophile is a resonance-stabilized acyl cation, generated by reaction between the acyl chloride and AlCl3 ... Auto-S-fatty acylated proteins represent a new class of potential drug targets, which often harbor lipid-binding hydrophobic pockets and reactive cysteine ... In combination with one of the strong acylating agents, the nucleophilic amines with no NH bonds undergo a fast acylation reaction that gives a cationic acyl ... by way of acylation with simple achiral acylating agents. Based on the experimental results observed, a transition state (TS) model involving π-interactions ...