What is the NF-κB signaling pathway in B cells?

Thus, CD40L/CD40 and MHC class II/T cell receptor (TCR) interactions are essential for peripheral B cell tolerance. The decreased numbers of CD4+ regulatory T ( ... As a result, VA expanded chronic lymphocytic leukemia to include all chronic B-cell leukemias as related to exposure to Agent Orange or other herbicides during ... Controversies Conference on Therapies Targeting B Cells in Immune-Mediated Kidney Diseases ... The goal of this KDIGO conference is to review the efficacy and ... B cells are essential for efficient immune responses and the maintenance of health. However, accumulating evidence points to the involvement of B cells in the ... Feb 19, 2018 ... Targeting of BTK, which has a central role in several signaling pathways in B cells, particularly the BCR, has shown impressive efficacy as ... Screening for common variable immunodeficiency and hyper-IgM syndromes. Assessing B-cell subset reconstitution after stem cell or bone marrow transplant. Centuori SM, Gomes CJ, Kim SS, Putnam CW, Larsen BT, Garland LL, Mount DW, Martinez JD. 2018. Double-negative (CD27IgD) B cells are expanded in NSCLC and ... Apr 3, 2017 ... These immune tolerance mechanisms function at various stages of B cell development. Central tolerance refers to the regulatory mechanisms that ... Feb 7, 2025 ... Researchers explore the role of B cells in non-lymphoid tissues, revealing new insights into infections, cancer, potential therapeutic breakthroughs. Apr 21, 2015 ... To date, two models of Breg cell development can be suggested. The first is that Breg cells, similar to thymus-derived Treg cells, are a ...