How can small molecule inhibitors be used to modulate B cell activity?

Arthur H. and Isabel Bunker Professor of Medicine (Hematology) and Professor of Immunobiology; Director, Center of Molecular and Cellular Oncology; Chief, ... The role of the CD19/CD21 complex in B cell processing and presentation of complement-tagged antigens. Fluorescence in situ hybridization (FISH) is a sensitive method to detect smaller genomic changes associated with various hematological malignancies and solid ... Sep 1, 2008 ... A simple definition of B lymphocytes is a population of cells that express clonally diverse cell surface immunoglobulin (Ig) receptors ... Mar 10, 2021 ... ... switching. Neuritin reduced differentiation of mouse and human GC B cells into plasma cells, downregulated BLIMP-1, and upregulated BCL6. ... B cells might play a critical role in disease pathogenesis. B cells and their antibodies have undisputed roles in health and disease within the airway ... May 28, 2019 ... Because we used to think that T cells were the major problem, DMTs often target those cells. But now we see that drugs targeting B cells are ... The finding gives oncologists a new target for developing immunotherapies: double negative memory B cells, so-called because they are negative for two markers. Lisocabtagene maraleucel for treating relapsed or refractory large B-cell lymphoma after first-line chemoimmunotherapy when a stem cell transplant is ... This type of activation produces memory and plasma B cells. Naïve B cells bind to soluble or membrane bound antigens and internalize the antigen. The B cell ...