What is affinity maturation of B cells?

abstract. Sputum examination is a useful noninvasive method to study airway inflammation. We investigated the reproducibility and validity of the ... The finding gives oncologists a new target for developing immunotherapies: double negative memory B cells, so-called because they are negative for two markers. Jun 18, 2019 ... T-cell lymphomas. T cells, much like B cells, are vital to our immune system. While B cells produce the antibodies that target diseased cells, T ... Dec 1, 2018 ... The chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel targets and eliminates CD19-expressing B cells and showed efficacy against B-cell lymphomas. What is primary mediastinal large B-cell lymphoma? Primary mediastinal large B-cell lymphoma (PMBCL) is a type of non-Hodgkin lymphoma (NHL). It is sometimes ... Sep 1, 2008 ... A simple definition of B lymphocytes is a population of cells that express clonally diverse cell surface immunoglobulin (Ig) receptors ... Feb 13, 2015 ... The immune system can remember a previously experienced pathogen and can evoke an enhanced response to reinfection that depends on memory lymphocyte ... ... B cells might play a critical role in disease pathogenesis. B cells and their antibodies have undisputed roles in health and disease within the airway ... Feb 7, 2025 ... Researchers explore the role of B cells in non-lymphoid tissues, revealing new insights into infections, cancer, potential therapeutic breakthroughs. ... cells, B cells, and plasma cells secreting pathogenic autoantibodies will be illuminated. The importance of cognate B cell help to autoreactive T cells will ...