How can interdisciplinary collaborations accelerate progress in germ cell research?

The initial step of spermatogenesis is the transition from male primitive germ cells (gonocytes) to undifferentiated spermatogonia in the neonatal testis. Qiaolin Deng is studying this migration and maturation to learn more about infertility, epigenetic inheritance and cancer. Additionally, the Department of Animal Biology houses the Penn Vet Center for Animal Transgenesis and Germ Cell Research, which enables the genetic manipulation ... "Germ Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Germ cell tumors are rare, accounting for about 1 percent of all childhood cancers. If your child is diagnosed with a germ cell tumor, you'll want a team with ... Report of the Validation of the IL-2 Luc Leukocyte Toxicity Test (IL-2 Luc LTT) Assay on In Vitro Immuno-Toxicity Testing Jun 8, 2006 ... Here we show that chicken PGCs can be isolated, cultured and genetically modified while maintaining their commitment to the germ line. We investigated this phenomenon using live-cell imaging and discovered that ectopic germ cells preferentially induce body-wall muscle to extend cellular ... Here, we show that the feminizing effect is inherent to germ cells and is not affected by gametogenic stages or the sexual fate of germ cells. Nov 30, 2020 ... Primordial germ cells (PGCs) are germline competent cells which form the functional gametes of the animal. The potential usage of avian PGCs ...