Can germ cells be reprogrammed into pluripotent stem cells?

We generated a gene-edited chicken, in which germ cells can be ablated in a drug-dependent manner, as recipients for gene-edited PGC transfer. Germ cell tumors in the testes of an adolescent male commonly present as an enlarging, solid mass, which may be painful. Within the ovaries, germ cell tumors ... Germ-line cells are responsible for transmitting genetic information and for reproducing totipotency from generation to generation. Pluripotent stem cell lines, ... Jun 8, 2006 ... Here we show that chicken PGCs can be isolated, cultured and genetically modified while maintaining their commitment to the germ line. Germ cell tumors of the brain most commonly involve or are found near the pituitary and pineal glands in the brain. Germ cells are used to produce human reproductive sex cells called gametes. Germ cells can either be diploid, or haploid (containing half the diploid chromosome ... Germ cells are forever. Cell. 2008 Feb 22;132(4):559-62. doi: 10.1016/j.cell.2008.02.003. Most germ cell tumors are treated with chemotherapy along with radiation therapy. Chemotherapy Treatment Radiation therapy Surgery The initial step of spermatogenesis is the transition from male primitive germ cells (gonocytes) to undifferentiated spermatogonia in the neonatal testis. Symptoms of germ cell tumors of the brain and spinal cord · Changes in endocrine function may cause: Slowed growth; Early or delayed puberty; Increased thirst ...