How can we tailor treatments based on an individual's renal function?

The kidneys are involved in the elimination of many drugs. The degree of renal excretion of an unchanged drug or its metabolites is the net result of glomerular ... Since the plasma creatinine level does not stand out, a normal renal function is presumed, and the doses of renal-clearance drugs are titrated consequently. The ... In conclusion, ionization state, lipophilicity, and polar descriptors are found to be the physicochemical determinants of renal clearance. These fundamental ... Renal excretion is quantitatively the most important route of excretion for most drugs and drug metabolites. Renal excretion involves three processes: ... Renal excretion of ingested Gastrografin is frequently visualized on CT in patients without anastomotic leakage during the early postoperative period after ... Augmented renal clearance (ARC) has been reported in children with malignancies and has been associated with subtherapeutic antibiotic concentrations. The most common Creatinine Clearance calculation, based on Cockcroft-Gault Equation. Sex: Male Female Age (years): Weight : kg lbs Serum Creatinine (mg/dL): Renal clearance is the rate at which a substance is removed from the blood plasma by the kidneys. Dalteparin. CrCl ≥30 mL/min: No adjustment. CrCl <30 mL/min: Use an anticoagulant with less dependence on renal clearance · CrCl ≥30 mL/min: No adjustment. Renal clearance is the process by which a substance in blood is filtered in the kidneys and then excreted in the urine.