What is the role of cytochrome P450 enzymes in Prozac's metabolism and half-life?

Mar 24, 2025 ... Fluoxetine's long half-life is an advantage and a drawback. If fluoxetine works well, an occasional missed dose is not a problem; if problems ... It is established that both fluoxetine and norfluoxetine have very long half-lives of 4–6 days and 4–16 days, respectively. Additionally, it has been reported ... Apr 17, 2023 ... Prozac works by inhibiting the reuptake of serotonin, allowing it to stay in the brain for longer periods and enhancing its effects. A sensitivity analysis found that removing responses involving fluoxetine, which has an especially long half-life, did not significantly alter this result. Apr 7, 2018 ... Brands with a relatively short half-life, like Effexor and Paxil, appear to cause more withdrawal symptoms more quickly than those that stay in ... Feb 24, 2022 ... It will take longer to leave the body completely. Specifically, it can take around 25 days or more for Prozac to leave your system. Discontinuation symptoms have been reported in association with selective serotonin reuptake inhibitors (SSRIs). Because of the long elimination half-life of ... Citalopram, escitalopram, fluoxetine and sertraline all have long half-lives (see table above: Half-lives and time to almost complete elimination - SSRIs). If ... Paroxetine is also troublesome while fluoxetine rarely causes withdrawal symptoms. (especially if the dose is under 40 mg) due to the long half-life of the ... The long half-life of the drug and its metabolite contribute to a 4-week period to reach steady-state concentrations. As with all available antidepressants ...