How does the pH of urine affect the excretion of Prozac and its metabolites?

Discontinuation symptoms have been reported in association with selective serotonin reuptake inhibitors (SSRIs). Because of the long elimination half-life of ... PO, metabolized in the liver primarily by CYP2D6, with fluoxetine (parent drug) having a half life of several day half life of 1-4 days · norfluoxetine is an ... May 23, 2022 ... The half-life of a drug is an estimate of the time it takes for the concentration or amount in the body of that drug to be reduced by exactly one-half (50%). As might be predicted from its primary site of metabolism, liver impairment can affect the elimination of fluoxetine. The elimination half-life of fluoxetine ... Jan 3, 2020 ... Paxil (paroxetine) and Prozac (fluoxetine) are SSRI ... Prozac comes as a daily or weekly oral capsule and has a long half-life of 4 to 6 days. Apr 6, 2023 ... And if you've been taking Prozac for a while, it takes about 4 to 6 days for your body to get rid of just half of it. For most people, it takes ... Jan 12, 2024 ... Despite its long-half life, symptoms associated with the discontinuation of PROZAC have been reported in clinical trials and post-marketing ... Apr 26, 2022 ... Fluoxetine has a half-life of 1–4 days and proved to be effective in the maintenance treatment of major depression and anxiety disorders ... In general, manufacturers advise caution (prolonged half-life). Hepatic impairment For fluoxetine. Dose adjustments. Manufacturer advises dose reduction or ... Sep 10, 2018 ... Fluoxetine has a half-life of 4–6 days, while its metabolite norfluoxetine has a half-life varying from 4 to 16 days. Risperidone is an ...