How does the long half-life of Prozac influence its effects on mood swings?

Apr 13, 2025 ... This compound has double the half-life of fluoxetine and has a half-life of anywhere from 4 to 15 days. It can take months for the body to get ... Discontinuation symptoms have been reported in association with selective serotonin reuptake inhibitors (SSRIs). Because of the long elimination half-life of ... The elimination half-life of fluoxetine is 48–72 h, averaging almost 70 h. The half-life of norfluoxetine is 7–9 days. The elimination half-lives for both ... The half-life of a medication is relevant to understanding its effects and potential withdrawal symptoms. Fluoxetine has a half-life of approximately 4-6 days. Because fluoxetine and its major metabolite, norfluoxetine, have long half-lives, a 6-week washout inter- val should be observed following discontinuation ... Fluoxetine (brand names: Prozac®, Reconcile®, Sarafem®) is an SSRI (selective serotonin reuptake inhibitor) antidepressant used to treat a variety of ... Apr 26, 2022 ... Fluoxetine has a half-life of 1–4 days and proved to be effective in the maintenance treatment of major depression and anxiety disorders ... Sertraline (Lustral®) – has a shorter half-life. The long half-life metabolite is only marginally active, unlike that in fluoxetine and hence is unlikely to ... Elimination: The elimination half-life of fluoxetine is 4 to 6 days and for norfluoxetine 4 to 16 days. These long half-lives are responsible for persistence of ... Citalopram, escitalopram, fluoxetine and sertraline all have long half-lives (see table above: Half-lives and time to almost complete elimination - SSRIs). If ...