What are the challenges in developing therapies that can specifically modulate the immune response in the brain without causing widespread immunosuppression?

Nov 10, 2022 ... Here, we report a case of AIE following severe traumatic brain injury (TBI), focusing on the challenges in diagnosis and management. Symptoms of autoimmune encephalitis · Impaired memory and understanding · Unusual and involuntary movements · Involuntary movements of the face (facial ... Sep 3, 2024 ... Autoantibodies against neuronal membrane proteins can manifest in autoimmune encephalitis, inducing seizures, cognitive dysfunction and ... Jun 1, 2017 ... Autoimmune encephalitis is a relatively new category of immune-mediated disease involving the central nervous system that demonstrates a widely variable ... Aug 1, 2021 ... Symptoms typically include subacute, progressive neuropsychiatric symptoms with associated cognitive dysfunction, movement disorders, and ... What is Autoimmune encephalitis ... This information is provided by the National Institutes of Health (NIH) Genetic and Rare Diseases Information Center (GARD). ... autoimmune encephalitis in our patient. Further, a negative imaging screen for underlying neoplasms argues against an underlying paraneoplastic process in ... Autoimmune encephalitis associated to antibodies against the N-methyl-D-aspartate receptor: Report of two cases. Biomédica [online]. 2017, vol.37, suppl.1 ... Sleep disorders are frequent, often severe, and usually persist beyond the acute disease stage, interfering with patients' recovery and quality of life. Treatment for suspected autoimmune encephalitis is often given empirically prior to specific antibody test results. This may include steroids and/or IVIG. If a ...