How can observational studies be made more rigorous to reduce bias?

Jan 22, 2021 ... The aim of this randomized, double-blind phase II/III study was to assess the efficacy of axitinib in patients with advanced G1-2 extra-pancreatic NETs. Rituximab depletes B cells and may reduce the production of autoantibodies against PLA2R or THSD7A. Therefore, the measurement of autoantibodies in participants ... The purpose of this research trial is to investigate the effects of LY3437943 (drug) compared with placebo on renal function, in participants who are ... Sep 17, 2012 ... In a randomized double-blind study (n = 127), science faculty from research-intensive universities rated the application materials of a ... A Phase 3, Multicenter, Randomized, Placebo-controlled, Double-blind Study to Evaluate the Efficacy and Safety of Lanadelumab for Prevention Against Acute ... A randomized, double-blind, multicenter study was conducted to investigate the boosting effect. Havrix in 537 healthy adults 18-53 years of age who had ... Jul 12, 2009 ... ... double-blind study in partial responders. A.C Altamura. ,. I Velonà. ,. R ... double-blind study, 28 patients with DSM-IV paranoid ... Jun 27, 2018 ... This research study is being done to compare the effectiveness of either 15 or 30 mg once daily of upadacitinib versus adalimumab versus a placebo to control ... ... trials. We conducted a randomized, double-blinded, 7 arm clinical trial to: (1) identify the presence of a dose-response for complete protection from emesis ... Nov 9, 2018 ... A randomized, controlled double-blind study comparing the efficacy and safety of dose-ranging voclosporin with placebo in achieving remission in patients with ...